Sarafianos, Stefan G.: search on Z-Library

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1

Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

Stefan G. Sarafianos, Bruno Marchand, Kalyan Das, Daniel M. Himmel, Michael A. Parniak, Stephen H. Hughes, Eddy Arnold

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 918 KB

english, 2009

2

Similarities and differences in the RNase H activities of human immunodeficiency virus type 1 reverse transcriptase and moloney murine leukemia virus reverse transcriptase

Hong-Qiang Gao, Stefan G Sarafianos, Edward Arnold, Stephen H Hughes

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 622 KB

english, 1999

3

Future treatment strategies for novel Middle East respiratory syndrome coronavirus infection

Adedeji, Adeyemi O, Sarafianos, Stefan G

Journal:

Future Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 922 KB

english, 2013

4

Design, Synthesis and Biological Evaluations of Hydroxypyridone Carboxylic Acids as Inhibitors of HIV Reverse Transcriptase-Associated RNase H

kankanala, jayakanth, Kirby, Karen A., Liu, Feng, Miller, Lena G., Nagy, Eva, Wilson, Daniel J., Parniak, Michael A, Sarafianos, Stefan G., Wang, Zhengqiang

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.12 MB

english, 2016

5

Drug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors

Singh, Kamalendra, Flores, Jacqueline, Kirby, Karen, Neogi, Ujjwal, Sonnerborg, Anders, Hachiya, Atsuko, Das, Kalyan, Arnold, Eddy, McArthur, Carole, Parniak, Michael, Sarafianos, Stefan

Journal:

Year:

2014

Language:

english

File:

PDF, 2.22 MB

english, 2014

6

Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase

Singh, Kamalendra, Marchand, Bruno, Kirby, Karen A., Michailidis, Eleftherios, Sarafianos, Stefan G.

Journal:

Year:

2010

Language:

english

File:

PDF, 2.64 MB

english, 2010

7

Visualization of HIV-1 RNA Transcription from Integrated HIV-1 DNA in Reactivated Latently Infected Cells

Ukah, Obiaara, Puray-Chavez, Maritza, Tedbury, Philip, Herschhorn, Alon, Sodroski, Joseph, Sarafianos, Stefan

Journal:

Year:

2018

Language:

english

File:

PDF, 2.00 MB

english, 2018

8

Reverse transcriptase in motion: Conformational dynamics of enzyme–substrate interactions

Matthias Götte, Jason W. Rausch, Bruno Marchand, Stefan Sarafianos, Stuart F.J. Le Grice

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2010

Language:

english

File:

PDF, 1.83 MB

english, 2010

9

5-Aminothiophene-2,4-dicarboxamide analogues as hepatitis B virus capsid assembly effectors

Tang, Jing, Huber, Andrew D., Pineda, Dallas L., Boschert, Kelsey N., Wolf, Jennifer J., Kankanala, Jayakanth, Xie, Jiashu, Sarafianos, Stefan G., Wang, Zhengqiang

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.30 MB

english, 2018

10

Remembering Professor Walter A. Scott

Sarafianos, Stefan

Journal:

Year:

2014

Language:

english

File:

PDF, 223 KB

english, 2014

11

HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site

Himmel, Daniel M., Sarafianos, Stefan G., Dharmasena, Sanjeewa, Hossain, Mohammed M., McCoy-Simandle, Kessler, Ilina, Tatiana, Clark, Arthur D., Knight, Jennifer L., Julias, John G., Clark, Patrick K.

Journal:

ACS Chemical Biology

Year:

2006

Language:

english

File:

PDF, 1.04 MB

english, 2006

12

6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase

Tang, Jing, Kirby, Karen A., Huber, Andrew D., Casey, Mary C., Ji, Juan, Wilson, Daniel J., Sarafianos, Stefan G., Wang, Zhengqiang

Journal:

European Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.37 MB

english, 2017

13

Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase

Tang, Jing, Vernekar, Sanjeev Kumar V., Chen, Yue-Lei, Miller, Lena, Huber, Andrew D., Myshakina, Nataliya, Sarafianos, Stefan G., Parniak, Michael A., Wang, Zhengqiang

Journal:

European Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 2.04 MB

english, 2017

14

Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) using pre-steady-state kinetics

Muftuoglu, Yagmur, Sohl, Christal D., Mislak, Andrea C., Mitsuya, Hiroaki, Sarafianos, Stefan G., Anderson, Karen S.

Journal:

Antiviral Research

Year:

2014

Language:

english

File:

PDF, 678 KB

english, 2014

15

Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker

Tang, Jing, Do, Ha T., Huber, Andrew D., Casey, Mary C., Kirby, Karen A., Wilson, Daniel J., Kankanala, Jayakanth, Parniak, Michael A., Sarafianos, Stefan G., Wang, Zhengqiang

Journal:

European Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 1.82 MB

english, 2019

16

CODAS Syndrome Is Associated with Mutations of LONP1, Encoding Mitochondrial AAA+ Lon Protease

Strauss, Kevin A., Jinks, Robert N., Puffenberger, Erik G., Venkatesh, Sundararajan, Singh, Kamalendra, Cheng, Iteen, Mikita, Natalie, Thilagavathi, Jayapalraja, Lee, Jae, Sarafianos, Stefan, Benkert,

Journal:

The American Journal of Human Genetics

Year:

2015

Language:

english

File:

PDF, 2.49 MB

english, 2015

17

4′-Ethynyl-2-fluoro-2′-deoxyadenosine, MK-8591

Markowitz, Martin, Sarafianos, Stefan G.

Journal:

Current Opinion in HIV and AIDS

Year:

2018

Language:

english

File:

PDF, 395 KB

english, 2018

18

Contribution of a multifunctional polymerase region of foot-and-mouth disease virus to lethal mutagenesis

de la Higuera, Ignacio, Ferrer-Orta, Cristina, Moreno, Elena, de Ávila, Ana Isabel, Soria, María Eugenia, Singh, Kamalendra, Caridi, Flavia, Sobrino, Francisco, Sarafianos, Stefan G., Perales, Celia,

Journal:

Journal of Virology

Year:

2018

Language:

english

File:

PDF, 2.36 MB

english, 2018

19

Structural Implications of Genotypic Variations in HIV-1 Integrase From Diverse Subtypes

Rogers, Leonard, Obasa, Adetayo E., Jacobs, Graeme B., Sarafianos, Stefan G., Sönnerborg, Anders, Neogi, Ujjwal, Singh, Kamalendra

Journal:

Frontiers in Microbiology

Year:

2018

Language:

english

File:

PDF, 1.98 MB

english, 2018

20

The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase

Hong-Qiang Gao, Paul L Boyer, Stefan G Sarafianos, Edward Arnold, Stephen H Hughes

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 614 KB

english, 2000

21

Expression and purification of SARS coronavirus proteins using SUMO-fusions

Xun Zuo, Michael R. Mattern, Robin Tan, Shuisen Li, John Hall, David E. Sterner, Joshua Shoo, Hiep Tran, Peter Lim, Stefan G. Sarafianos, Lubna Kazi, Sonia Navas-Martin, Susan R. Weiss, Tauseef R. But

Journal:

Protein Expression and Purification

Year:

2005

Language:

english

File:

PDF, 751 KB

english, 2005

22

In vitro transport characteristics of EFdA, a novel nucleoside reverse transcriptase inhibitor using Caco-2 and MDCKII cell monolayers

Zhang, Wei, Parniak, Michael A., Sarafianos, Stefan G., Empey, Philip E., Rohan, Lisa C.

Journal:

European Journal of Pharmacology

Year:

2014

Language:

english

File:

PDF, 499 KB

english, 2014

23

Determinants of Active-Site Inhibitor Interaction with HIV-1 RNase H

Xi, Zhaoyong, Wang, Zhengqiang, Sarafianos, Stefan G., Myshakina, Nataliya S., Ishima, Rieko

Journal:

ACS Infectious Diseases

Year:

2019

File:

PDF, 7.12 MB

2019

24

Publisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

Francis, Ashwanth C., Marin, Mariana, Singh, Parmit K., Achuthan, Vasudevan, Prellberg, Mathew J., Palermino-Rowland, Kristina, Lan, Shuiyun, Tedbury, Philip R., Sarafianos, Stefan G., Engelman, Alan

Journal:

Nature Communications

Year:

2020

File:

PDF, 307 KB

2020

25

Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity

Kimani, Stanley G., Kumar, Sushil, Bansal, Nitu, Singh, Kamalendra, Kholodovych, Vladyslav, Comollo, Thomas, Peng, Youyi, Kotenko, Sergei V., Sarafianos, Stefan G., Bertino, Joseph R., Welsh, William

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 1.70 MB

english, 2017

26

Impact of HIV-1 Integrase L74F/V75I Mutations from a Clinical Isolate on Resistance to Second-Generation Integrase Strand Transfer Inhibitors

Hachiya, Atsuko, Kirby, Karen A., Ido, Yoko, Shigemi, Urara, Matsuda, Masakazu, Okazaki, Reiko, Imamura, Junji, Sarafianos, Stefan G., Yokomaku, Yoshiyuki, Iwatani, Yasumasa

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2017

Language:

english

File:

PDF, 2.00 MB

english, 2017

27

Ex vivo antiretroviral potency of newer integrase strand transfer inhibitors cabotegravir and bictegravir in HIV-1 non-B subtypes

Neogi, Ujjwal, Singh, Kamlendra, Aralaguppe, Shambhu G., Rogers, Leonard C., Njenda, Duncan T., Sarafianos, Stefan G., Hejdeman, Bo, Sönnerborg, Anders

Journal:

Year:

2017

Language:

english

File:

PDF, 906 KB

english, 2017

28

Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4

Kazuki Shimane, Eiichi N. Kodama, Ikuhiko Nakase, Shiroh Futaki, Yasuteru Sakurai, Yasuko Sakagami, Xiaoguang Li, Toshio Hattori, Stefan G. Sarafianos, Masao Matsuoka

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2010

Language:

english

File:

PDF, 753 KB

english, 2010

29

Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097

Kalyan Das, Stefan G. Sarafianos, Arthur D. Clark Jr, Paul L. Boyer, Stephen H. Hughes, Eddy Arnold

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.11 MB

english, 2007

30

Introducing Our Authors

Hang, Howard C., Warthaka, Mangalika, Worthington, Andrew, Sayut, Daniel J., Himmel, Daniel M., Sarafianos, Stefan G.

Journal:

ACS Chemical Biology

Year:

2006

Language:

english

File:

PDF, 676 KB

english, 2006

31

Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H

Kankanala, Jayakanth, Kirby, Karen A., Huber, Andrew D., Casey, Mary C., Wilson, Daniel J., Sarafianos, Stefan G., Wang, Zhengqiang

Journal:

European Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.36 MB

english, 2017

32

Molecular biology: An HIV secret uncovered

Arnold, Eddy, Sarafianos, Stefan G.

Journal:

Year:

2008

Language:

english

File:

PDF, 451 KB

english, 2008

33

Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus

de la Higuera, Ignacio, Ferrer-Orta, Cristina, de Ávila, Ana I., Perales, Celia, Sierra, Macarena, Singh, Kamalendra, Sarafianos, Stefan G., Dehouck, Yves, Bastolla, Ugo, Verdaguer, Nuria, Domingo, Es

Journal:

Genome Biology and Evolution

Year:

2017

Language:

english

File:

PDF, 839 KB

english, 2017

34

D-101 Structural Basis of Inhibition and Resistance Mechanism to EFdA, a highly potent NRTI

Sarafianos, Stefan

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Year:

2017

Language:

english

File:

PDF, 2.69 MB

english, 2017

35

6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H

Wang, Lei, Tang, Jing, Huber, Andrew D., Casey, Mary C., Kirby, Karen A., Wilson, Daniel J., Kankanala, Jayakanth, Parniak, Michael A., Sarafianos, Stefan G., Wang, Zhengqiang

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.85 MB

english, 2018

36

Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches toward Inhibiting Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

Wang, Lei, Sarafianos, Stefan G., Wang, Zhengqiang

Journal:

Accounts of Chemical Research

Year:

2019

Language:

english

File:

PDF, 6.26 MB

english, 2019

37

Combining mutations in HIV-1 reverse transcriptase with mutations in the HIV-1 polypurine tract affects RNase H cleavages involved in PPT utilization

Mary Jane McWilliams, John G. Julias, Stefan G. Sarafianos, W. Gregory Alvord, Eddy Arnold, Stephen H. Hughes

Journal:

Year:

2006

Language:

english

File:

PDF, 519 KB

english, 2006

38

Antiviral drugs specific for coronaviruses in preclinical development

Adedeji, Adeyemi O, Sarafianos, Stefan G

Journal:

Current Opinion in Virology

Year:

2014

Language:

english

File:

PDF, 930 KB

english, 2014

39

Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries

Neogi, Ujjwal, Häggblom, Amanda, Singh, Kamalendra, Rogers, Leonard C., Rao, Shwetha D., Amogne, Wondwossen, Schülter, Eugen, Zazzi, Maurizio, Arnold, Eddy, Sarafianos, Stefan G., Sönnerborg, Anders

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2016

Language:

english

File:

PDF, 342 KB

english, 2016

40

Increased replication capacity following evolution of PYxE insertion in Gag-p6 is associated with enhanced virulence in HIV-1 subtype C from East Africa

Aralaguppe, Shambhu G., Winner, Dane, Singh, Kamalendra, Sarafianos, Stefan G., Quiñones-Mateu, Miguel E., Sönnerborg, Anders, Neogi, Ujjwal

Journal:

Journal of Medical Virology

Year:

2016

Language:

english

File:

PDF, 867 KB

english, 2016

41

Exposing HIV's weaknesses

Tedbury, Philip R., Sarafianos, Stefan G.

Journal:

Journal of Biological Chemistry

Year:

2017

Language:

english

File:

PDF, 308 KB

english, 2017

42

6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity

Wang, Lei, Tang, Jing, Huber, Andrew D., Casey, Mary C., Kirby, Karen A., Wilson, Daniel J., Kankanala, Jayakanth, Xie, Jiashu, Parniak, Michael A., Sarafianos, Stefan G., Wang, Zhengqiang

Journal:

European Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.56 MB

english, 2018

43

Glycosylated diphyllin as a broad-spectrum antiviral agent against Zika virus

Martinez-Lopez, Alicia, Persaud, Mirjana, Chavez, Maritza Puray, Zhang, Hongjie, Rong, Lijun, Liu, Shufeng, Wang, Tony T., Sarafianos, Stefan G., Diaz-Griffero, Felipe

Journal:

Year:

2019

Language:

english

File:

PDF, 3.85 MB

english, 2019

44

Synthesis of boranoate, selenoate, and thioate analogs of AZTp4A and Ap4A

Qianwei Han, Stefan G. Sarafianos, Eddy Arnold, Michael A. Parniak, Barbara L. Gaffney, Roger A. Jones

Journal:

Year:

2009

Language:

english

File:

PDF, 266 KB

english, 2009

45

3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations

Tang, Jing, Liu, Feng, Nagy, Eva, Miller, Lena, Kirby, Karen A., Wilson, Daniel J., Wu, Bulan, Sarafianos, Stefan G., Parniak, Michael A., Wang, Zhengqiang

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.04 MB

english, 2016

46

Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

Vernekar, Sanjeev Kumar V., Liu, Zheng, Nagy, Eva, Miller, Lena, Kirby, Karen A., Wilson, Daniel J., Kankanala, Jayakanth, Sarafianos, Stefan G., Parniak, Michael A., Wang, Zhengqiang

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.13 MB

english, 2015

47

Long-Acting Anti-HIV Drugs Targeting HIV-1 Reverse Transcriptase and Integrase

Singh, Kamal, Sarafianos, Stefan G., Sönnerborg, Anders

Journal:

Pharmaceuticals

Year:

2019

File:

PDF, 792 KB

2019

48

Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody fab fragment at 2.8 Å resolution

Jianping Ding, Kalyan Das, Yu Hsiou, Stefan G Sarafianos, Arthur D Clark Jr, Alfredo Jacobo-Molina, Chris Tantillo, Stephen H Hughes, Edward Arnold

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 1.50 MB

english, 1998

49

Multifunctionality of a Picornavirus Polymerase Domain: Nuclear Localization Signal and Nucleotide Recognition

Ferrer-Orta, Cristina, de la Higuera, Ignacio, Caridi, Flavia, Sánchez-Aparicio, María Teresa, Moreno, Elena, Perales, Celia, Singh, Kamalendra, Sarafianos, Stefan G., Sobrino, Francisco, Domingo, Est

Journal:

Journal of Virology

Year:

2015

File:

PDF, 6.66 MB

2015

50

The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase

Takamatsu, Yuki, Das, Debananda, Kohgo, Satoru, Hayashi, Hironori, Delino, Nicole S., Sarafianos, Stefan G., Mitsuya, Hiroaki, Maeda, Kenji

Journal:

Cell Chemical Biology

Year:

2018

Language:

english

File:

PDF, 2.40 MB

english, 2018

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